• Minoxidil Powder
    Product name: Minoxidil Synonyms:  INCI name: Minoxidil CAS No.: 38304-91-5 EINECS: 253-874-2 Quality: USP43 Molecular formula:C9H15N5O Molecular weight: 209.25   Description: Minoxidil was first introduced as an antihypertensive medication and the discovery of its common adverse event, hypertrichosis, led to the development of a topical formulation for promoting hair growth. To date, topical minoxidil is the mainstay treatment for androgenetic alopecia and is used as an off-label treatment for other hair loss conditions. Despite its widespread application, the exact mechanism of action of minoxidil is still not fully understood. In this article, we aim to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.   Minoxidil also works by increasing the supply of blood and nutrients to your hair follicles helping to strengthen the existing hairs and encouraging them to grow   Minoxidil is the only over- the-counter active ingredient clinically proven to help stop and even reverse hereditary hair loss, by reactivating your inactive hair follicles.   The mechanism by which minoxidil stimulates hair growth is not fully understood, but minoxidil can help reverse the hair loss process of androgenetic alopecia by the following means:   Reverses the miniaturisation of follicles Increases blood flow around follicles Stimulates follicle movement to growth phase Extends each follicle growth phase     Specification (USP43):   Items Specifications Appearance White to off-white crystal powder Identification IR: similar to the reference standard Melting point 248-268℃ Solubility Soluble in propylene glycol, sparingly soluble in methanol. Slightly soluble in water. Practically insoluble in chloroform, in acetone, in ethyl acetate and in hexane. Residue on ignition ≤0.5% Elemental impurities ≤20ppm Loss on drying ≤0.5% Organic volatile impurities Meet the requirements Residual solvents Methanol≤3000ppm Ethanol≤5000ppm Ethyl acetate≤5000ppm Total impurities ≤1.5% Assay(HPLC) 97~103%       Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • L-Glutathione oxidized -Bismancosmetic
    L-Glutathione oxidized
    Product name: L-Glutathione oxidized Synonyms: GSSG INCI name: oxidized Glutathione CAS No.: 27025-41-8 EINECS: 248-170-7 Quality: assay 98% up by HPLC Molecular formula:C20H32N6O12S2 Molecular weight: 612.63   Description: Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. Glutathione, Oxidized (GSSG) is the oxidized version of the naturally occurring and very important antioxidant glutathione (GSH). In vivo GSSG is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, therefore beeing an important bioindicator of cellular health. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. GSSG, along with glutathione and S-nitrosoglutathione (GSNO), have been found to bind to the glutamate recognition site of the NMDA and AMPA receptors (via their γ-glutamyl moieties), and may be endogenous neuromodulators. GSSG can be used as substrate for enzymatically assaying glutathione reductase.     Specification (assay 98% up by HPLC): Items Standards Appearance White crystalline powder Odor Odorless to faint odor Identification (IR) Pass test Identification (HPLC) Pass test State of solution Colorless to yellowish clear Specific rotation (at 25℃) -103° to -93° Heavy metal (As Pb), mg/kg ≤20 Moisture, % ≤6.0 Residue on ignition, % ≤0.5 Ethanol, % ≤0.05 Single unknown impurity ≤1 Total unknown impurity ≤2 Total unknown impurity ≤4 Total plate count, cfu/g ≤100 Assay, % ≥98.0     Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • L-Glutathione reduced -Bismancosmetic
    L-Glutathione reduced
    Product name: L-Glutathione reduced Synonyms: GSH INCI name: Glutathione CAS No.: 70-18-8 EINECS: 206-169-9 Quality: assay 98% up by HPLC Molecular formula:C10H17N3O6S Molecular weight: 307.32   Description: L-Glutathione (GSH) reduced has been used in the elution buffer to elute GST (glutathione S-transferase)-fused proteins using glutathione-agarose beads. It has been used to prepare a standard curve for GSH analyses. May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.   Glutathione is an antioxidant produced in cells. It’s comprised largely of three amino acids: glutamine, glycine, and cysteine.   Glutathione levels in the body may be reduced by a number of factors, including poor nutrition, environmental toxins, and stress. Its levels also decline with age.   In addition to being produced naturally by the body, glutathione can be given intravenously, topically, or as an inhalant. It’s also available as an oral supplement in capsule and liquid form. However, oral ingestion of glutathione may not be as effectiveTrusted Source as intravenous delivery for some conditions.   Glutathione benefits 1. Reduces oxidative stress 2. May improve psoriasis 3. Reduces cell damage in alcoholic and nonalcoholic fatty liver disease 4. Improves insulin resistance in older individuals 5. Increases mobility for people with peripheral artery disease 6. Reduces symptoms of Parkinson’s disease 7. May help fight against autoimmune disease 8. May reduce oxidative damage in children with autism 9. May reduce the impact of uncontrolled diabetes 10. May reduce respiratory disease symptoms         Specification (USP43): Items Standards Appearance White or almost white crystalline powder Appearance of Solution Clear and colorless (10% w/v in water) Bulk Density ≥0.40g/ml Tapped Density ≥0.60g/ml Mesh Size 100% thru mesh 80 Identification S.O.R: -15.5°~-17.5°   Infrared: Positive Related Substances L-glutathione oxidized ≤1.5%   Total impurities ≤2.0% Assay (dry basis) 98.0%~101.0% Loss on Drying (3h at 105℃) ≤0.5% Residue on Ignition ≤0.1% Ammonium ≤200ppm Chloride ≤200ppm Sulfate ≤300ppm Iron ≤10ppm Arsenic ≤1.0ppm Cadmium ≤0.2ppm Lead ≤0.5ppm Mercury ≤0.3ppm Heavy Metals ≤10ppm Total Plate Count ≤1000cfu/g Yeast & Mold ≤100cfu/g Coliforms Negative/1g E.Coli Negative/10g Salmonella Negative/10g Staphylococcus Aureus Negative/10g         Specification (EP10): Items Standards Appearance White or almost white, crystalline powder or colorless crystals Solubility Freely soluble in water, very slightly soluble in ethanol and in methylene chloride Identification S.O.R.:-15.5°~-17.5°   Infrared: Conforms to the Reference Spectrum Appearance of solution Clear and colorless Specific optical rotation -15.5°~-17.5° Related substances -Impurity A (L-cysteinylglycine)≤0.5%   -Impurity B (Cysteine)≤0.5%   -Impurity C (L-glutathione oxidised)≤1.5%   -Impurity D (L-γ-glutamyl-L-cysteine)≤1.0%   -Impurity E (Product of degradation)≤0.5%   Total Impurities≤2.5% Chlorides ≤200ppm Sulphates ≤300ppm Ammonium ≤200ppm Iron ≤10ppm Heavy Metals ≤10ppm Loss on Drying ≤0.5% Sulfated ash ≤0.1% Bacterial Endotoxin ≤0.1EU/mg Assay 98.0% to 101.0%       Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • L-Carnosine -Bismancosmetic
    Product name: L-Carnosine Synonyms: - INCI name: Carnosine CAS No.: 305-84-0 EINECS: 206-169-9 Quality: assay 98% up by HPLC Molecular formula:C9H14N4O3 Molecular weight: 226.23   Description: Carnosine is a protein building block that is naturally produced in the body. It is concentrated in muscles when they are working, and it is also found in the heart, brain, and many other parts of the body.   Carnosine is used to prevent aging and for preventing or treating complications of diabetes such as nerve damage, eye disorders (cataracts), and kidney problems.     It plays a crucial role in the production of energy by transporting fatty acids into your cells’ mitochondria (1Trusted Source, 2Trusted Source, 3Trusted Source).   The mitochondria act as engines within your cells, burning these fats to create usable energy.   Your body can produce L-carnitine out of the amino acids lysine and methionine.   For your body to produce it in sufficient amounts, you also need plenty of vitamin C (4Trusted Source).   In addition to the L-carnitine produced in your body, you can also obtain small amounts by eating animal products like meat or fish (5Trusted Source).   Vegans or people with certain genetic issues may be unable to produce or obtain enough. This makes L-carnitine a conditionally essential nutrient (6Trusted Source).     Carnosine is a substance produced naturally by the body. Classified as a dipeptide, a compound made up of two linked amino acids (in this case alanine and histidine), carnosine is highly concentrated in muscle tissue and in the brain. It's also present in significant concentrations in beef and fish, and in lower concentrations in chicken.     Specification (assay 99% up by HPLC): Items Specifications Appearance Off-white or white powder HPLC Identification Consistent with the reference substance main peak retention time Specific rotation +20.0°~+22.0° Heavy metals ≤10ppm pH 7.5~8.5 Loss on dry ≤1.0% Lead ≤3ppm Arsenic ≤1ppm Cadmium ≤1ppm Mercury ≤0.1ppm Melting point 250.0℃~265.0℃ Residue On ignition ≤0.1% Hydrazine ≤2ppm Bulk density - Tapped density - L-Histidine ≤0.3% Assay 99.0%~101.0% Total aerobic counts ≤1000CFU/g Mold &Yeast ≤1000CFU/g E.Coli Negative Sa1monella Negative     Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • Kojic acid -Bismancosmetic
    Kojic acid
    Product name: Kojic acid Synonyms: - INCI name: kojic acid CAS No.: 501-30-4 EINECS: 207-922-4 Quality: assay 98% up by HPLC Molecular formula: C6H6O4 Molecular weight: 142.11   Description: Kojic acid is made from several different types of fungi. It’s also a byproduct when certain foods ferment, including Japanese sake, soy sauce, and rice wine.   Kojic acid inhibits and prevents the formation of tyrosine, which is an amino acid that’s needed to produce melanin. Melanin is the pigment that affects hair, skin, and eye color. Because it inhibits the production of melanin, kojic acid can have a lightening effect.     Kojic’s acid primary use — and benefit — is to lighten visible sun damage, age spots, or scars. This can result in an anti-aging effect on the skin.   In addition to skin-lightening effects, kojic acid also contains some antimicrobial properties. It may help fight off several common types of bacterial strains even in small dilutions. This can help treat acne caused by bacteria in the skin. It may also lighten scars from acne that haven’t faded yet.   Kojic acid also has antifungal propertiesTrusted Source. It’s even added to some antifungal productsTrusted Source to increase their effectiveness. It may be useful in treating fungal infections of the skin like yeast infections, candidiasis, and ringworm or athlete’s foot. If soap containing kojic acid is used regularly, it may help prevent both bacterial and fungal infections on the body.       Specification (assay 99% up by HPLC): Items Specifications Appearance Almost white crystalline powder Assay ≥99.0% Melting point 152~156℃ Loss on drying ≤1% Ignition residue ≤0.2% Chloride ≤100 PPM Heavy metal ≤10 ppm       Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • S-Acetyl-L-glutathione -Bismancosmetic
    Product name: S-Acetyl-L-Glutathione Synonyms: SAG INCI name: - CAS No.: 3054-47-5 EINECS: 221-275-5 Quality: assay 98% up by HPLC Molecular formula: C12H19N3O7S Molecular weight: 349.36   Description: S-Acetyl Glutathione (S-A-GSH) is a unique form of glutathione, one of the most powerful antioxidants naturally produced in the body. It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule. S-A-GSH is well-suited for oral ingestion, because this acetyl group protects glutathione from breaking down in the gastrointestinal tract. Once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact. S-A-GSH helps to support immune function and to optimize glutathione-dependent hepatic detoxifi cation pathways. It is the perfect choice when higher doses of glutathione are recommended. This product also includes N-acetyl cysteine (NAC) and vitamin B6, both of which are important for the production of glutathione.   Specification (assay 98% up by HPLC): Items Standards Appearance A white to off-white powder Identification HPLC RT Loss on Drying ≤0.5% Residue on Ignition ≤0.2% Assay S-Acetyl-L-Glutathione≥98% GSH≤1.0% Ammonium ≤200ppm Chlorides ≤200ppm Sulfates ≤300ppm Iron ≤10ppm Heavy metals (Pb) ≤10ppm   Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
  • cysteamine hydrochloride in cosmetics
    Cysteamine HCL
    Product name: Cysteamine HCl Synonyms: cysteamine hydrochloride, cysteamine, cysteamin INCI name: Cysteamine CAS No.: 156-57-0 EINECS: 205-858-1 Quality: assay 99% up by HPLC Molecular formula: C2H8ClNS Molecular weight: 113.61   Description: Cysteamine hydrochloride is also used in cosmetics as an antioxidant, a hair straightening agent, and a hair waving agent. It functions as a reducing agent at concentrations between 5% and 12% in permanent-wave solutions The functions of the cosmetic ingredient ANTIOXIDANT : inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity. HAIR WAVING OR STRAIGHTENING : modifying the chemical structure of the hair, allowing it to be set in the style required (permanent waves or hair straightening). REDUCING : changing the chemical nature of another ingredient by adding hydrogen (or removing oxygen).     Specification (assay 99% up by HPLC): Test Item Specification Appearance White crystalline powder Identification Should conform Loss on Drying ≤0.5% Other reducing material ≤0.4ml Residue of ignition ≤0.25% pH 3.0~5.0 Melting point 66~70℃ Figuration Liquid is clear solution or limpid solution Arsenic content ≤2ppm Heavy Metals ≤10 ppm Iron ≤1.0ppm Assay Contains C2H7NS·HCl not less than 99.0%     Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum  
  • Coenzyme q10 Powder For Skin
    Coenzyme Q10
    Product name: Coenzyme Q10 Synonyms: Q10, CQ10, coq10 INCI name: - CAS No.: 303-98-0 EINECS: 206-147-9 Quality: EP10, USP43 Molecular formula: C59H90O4 Molecular weight: 863.34   Description: coenzyme Q10 (CoQ10 for short) is a naturally produced bodily enzyme and one of the most fundamental antioxidants. CoQ10 or Coenzyme Q-10 is a kind of fat-soluble quinone compoundCoenzyme Q10 is found in every cell of the human body. A coenzyme is a substance that enhances or is necessary for the action of enzymes, generally smaller than the enzymes. CoQ10 is vital in energy production in cells.     Benefits of CoQ10 for Skin While naturally occurring CoQ10 can be digested for energy, it can do a number of things in skincare products too. In terms of skincare, it's usually in toners, moisturizers, and under eye creams, helping to even skin tone and reduce the appearance of fine lines.   Energizes cell activity:  This energy is needed to repair damage and make sure the skin cells are healthy, Active skin cells get rid of toxins easily and can make better use of nutrients. When your skin ages, all these processes slow down, causing dull and sallow, wrinkled skin." CoQ10 can keep your cells active and energized, helping your cells rid themselves of toxins. Reduce sun damage:  The skin is damaged by exposure to the sun's UV rays, which provides a source of free radicals, which can be damaging to the cells' DNA,The potent antioxidant function of CoQ10 helps it to protect the skin at the molecular level from the damaging effects of the sun and from damage by free radicals." As Thomas explains, it works by "decreasing the collagen degradation of skin and interdicting the damage caused byphoto-aging." Even out skin tone:  CoQ10 works to block tyrosinase, which helps with the production of melanin, which means that CoQ10 can help fade and prevent dark spots.1 Stimulate collagen and elastin production: "CoQ10 supports the bodies ability to produce collagen and elastin,"  Replenishes skin cells:  More energized skin cells means healthier skin cells. Adding CoQ10 to your skincare may allow your cells to better utilize other nutrients, leading to healthier skin overall. Helps reduce damage of free radicals: Since CoQ10 aids in cell activity, it also means that your cells can be more efficient in flushing out toxins like free radicals and healing the damage they cause. Helps soothe skin: While toxins are being flushed out, your skin is silently thanking you. CoQ10 works to help your cells remove what's irritating cells and your skin. Reduces the appearance of wrinkles and fine lines:  This ingredient helps your body produce collagen and elastin, which can reduce the appearance of fine lines.2 According to Pruett, CoQ10 works similarly to another powerhouse ingredient: Vitamin C. The most common antioxidant applied topically for&n...
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