Product name: beta arbutin Synonyms: β-arbutin INCI name: - CAS No.: 497-76-7 EINECS: 207-850-3 Quality: assay 99.5% by HPLC Molecular formula: C12H16O7 Molecular weight: 272.25   Description: β-Arbutin is used as a whitening ingredient for controlling the generation of melanin pigments, which are substances causing discoloration and freckles. It is known as a substance contained in ericaceous herbs called bearberry leaf. Discoloration and freckles occur due to reactive oxygen produced in skin by exposure to UV in sunlight, stress, atmospheric pollution, etc., which activates tyrosinase and the activated enzyme promotes the conversion of tyrosine in melanocytes (pigment cells) to melanin pigments. β-Arbutin is said to demonstrate whitening effects by reducing the production of melanin pigments by working directly on tyrosinase in melanocytes.   Specification (assay 99.5% by HPLC): Test Items Standard Appearance White crystalline powder Assay 99.5% min Melting point 198.5-201.5℃ Clarity of water solution Transparency, colorless, none suspended matters PH value of 1% aqueous solution 5-7 Specific optical rotation [α]D20=-66±2° Arsenic ≤2ppm Hydroquinone ≤10ppm Heavy metal ≤10ppm Loss on drying ≤0.5% Ignition residue ≤0.5% Pathogen Bacteria ≤300cfu/g Fungus ≤100cfu/g   Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum

Product name: Minoxidil Synonyms:  INCI name: Minoxidil CAS No.: 38304-91-5 EINECS: 253-874-2 Quality: USP43 Molecular formula:C9H15N5O Molecular weight: 209.25   Description: Minoxidil was first introduced as an antihypertensive medication and the discovery of its common adverse event, hypertrichosis, led to the development of a topical formulation for promoting hair growth. To date, topical minoxidil is the mainstay treatment for androgenetic alopecia and is used as an off-label treatment for other hair loss conditions. Despite its widespread application, the exact mechanism of action of minoxidil is still not fully understood. In this article, we aim to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.   Minoxidil also works by increasing the supply of blood and nutrients to your hair follicles helping to strengthen the existing hairs and encouraging them to grow   Minoxidil is the only over- the-counter active ingredient clinically proven to help stop and even reverse hereditary hair loss, by reactivating your inactive hair follicles.   The mechanism by which minoxidil stimulates hair growth is not fully understood, but minoxidil can help reverse the hair loss process of androgenetic alopecia by the following means:   Reverses the miniaturisation of follicles Increases blood flow around follicles Stimulates follicle movement to growth phase Extends each follicle growth phase     Specification (USP43):   Items Specifications Appearance White to off-white crystal powder Identification IR: similar to the reference standard Melting point 248-268℃ Solubility Soluble in propylene glycol, sparingly soluble in methanol. Slightly soluble in water. Practically insoluble in chloroform, in acetone, in ethyl acetate and in hexane. Residue on ignition ≤0.5% Elemental impurities ≤20ppm Loss on drying ≤0.5% Organic volatile impurities Meet the requirements Residual solvents Methanol≤3000ppm Ethanol≤5000ppm Ethyl acetate≤5000ppm Total impurities ≤1.5% Assay(HPLC) 97~103%       Production capacity: 1000kg/month Storage condition: Stored in cool, dry place, room temperature. Package material: drum Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum

1. GMP room 2. Synthetis 3. Fernentation 4. Water system 5. Sieve 6. Test 7. Storage

The company carry out GMP management with thorough quality assurance system. Our quality inspection center is equipped with physical and chemical room, microtest room, balance room, liquid phase room, atomic absorption room, atomic fluorescence room, high greenhouse, calibration room, reagent room, hazardous chemicals room, sample room. Quality inspection department is responsible for monitoring of raw material used for the company’s production, finished product, intermediate, checking on process water and environmental condition.  High-quality quality inspection team provides important guarantee for the company’s product quality. Quality inspection department is equipped with domestic first-class analysis and detection equipment, including nearly 30 high performance liquid chromatograph and gas chromatograph, infrared spectrometer, ultraviolet-visible spectrophotometer, differential refractive detector, abbe optical analyzer, digital display type automatic polarimeter, moisture analyzer and so on. It fully owns and meets requirement of scientific monitoring, quality analysis of raw material, intermediate and finished product, and control research. uality management department takes responsibility for establishing and perfecting of the company’s quality supervision system. It arranges full-time QA personnel to conduct monitoring on the overall process including comment on raw material supplier, procurement of raw material, warehouse entry inspection, production process, release of end product, sales, customer feedback and so on, standardizes and perfects all kinds of quality management system, manages the company’s whole quality system by means of on site patrol inspection, regular inspection and regular quality report at the same time, and regularly organizes training of updated GMP knowledge to improve the staff’s quality consciousness and establish their quality concept.